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Muscle Pain or Myalgia

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31/01/2024


Muscle Pain or Myalgia

Muscle Pain (Myalgia)

Muscle pain, or myalgia, refers to discomfort affecting specific muscle groups or the entire body. It is often caused by muscle contraction and may or may not involve inflammation. Common causes include overuse, tension, strain, or stretching due to excessive force.

Additionally, muscle pain may be associated with underlying conditions such as autoimmune diseases (e.g., polymyositis, dermatomyositis, lupus ), infections (e.g., muscle abscesses caused by Staphylococcus, trichinosis ), or systemic infections (e.g., influenza, malaria, Rocky Mountain spotted fever, polio, leptospirosis, measles, and rheumatic fever).

In most cases, muscle pain resolves spontaneously with adequate rest. However, persistent or recurrent pain may indicate underlying pathology and should be promptly addressed.

When to See a Doctor

  • Muscle pain lasting more than 3 days
  • Severe pain without a known cause
  • Signs of infection (e.g., swelling, redness around the affected area)
  • Poor circulationin the painful area
  • Associated rash or recent tick bite
  • Pain onset related to medication(e.g., statins)

Patient Advice

Prevention

  • Warm up and stretch before exercise, especially before swimming or high-intensity workouts.
  • Learn proper exercise techniques or consult a certified trainer.
  • Avoid strenuous exercise or heavy lifting when injured or experiencing pain.
  • Take breaks to stretch every hour when remaining in the same posture for extended periods.

Self-Management: PRICE Principle

  • Protect – Stop activity immediately when pain begins to prevent further injury.
  • Restrict – Rest the injured area and minimize movement for at least 72 hours.
  • Ice/Cool – Apply cold packs to reduce swelling and inflammation.
  • Compress – Wrap the injured area with an elastic bandage after icing to minimize swelling.
  • Elevate – Raise the injured limb above heart level to improve blood flow and reduce swelling.

Treatment Options

1.

  • Paracetamol: A mild analgesic that can be taken 3–4 times daily to relieve muscle pain.
  • Capsaicin cream: Beneficial for neuritic pain characterized by burning, tingling, or needle-like sensations. Derived from chili extract, it inhibits nerve signal transmission at the application site. Multiple daily applications are required for optimal results.
  • Opioid analgesics (e.g.,tramadol): May be used for moderate to severe pain or in patients unable to take NSAIDs due to allergies or poor response. Use requires close medical supervision.

2. Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

NSAIDs are widely used for relieving joint pain and swelling by inhibiting prostaglandin synthesis. Common side effects include gastrointestinal irritation or ulcers and increased risk of cardiovascular events and acute renal failure in certain patients. Therefore, their use should always be evaluated by a physician or pharmacist.

NSAID Dosage and Administration in Adults

Drug Adult Dosage (D) Administration (A)
Loxoprofen 60 mg three times daily or 120 mg once daily Take with or immediately after food
Aspirin 300–900 mg every 4–6 hours (max 4,000 mg/day) Take with or immediately after food
Mefenamic acid 250–500 mg three times daily Take with or immediately after food
Meloxicam 7.5–15 mg once daily (max 15 mg/day) Take with or after food if gastric irritation occurs
Diclofenac Tab: 50 mg 2–3 times/day; DR tab: 75–100 mg/day in 2–3 doses; ER tab: 75–100 mg/day Take with or immediately after food
Nabumetone 1,000 mg once daily; additional 500–1,000 mg in morning if needed (max 2,000 mg/day) Take with or immediately after food to reduce gastric irritation
Etodolac Cap: 200 mg every 6–8 hrs or 400 mg every 12 hrs (max 1,000 mg/day); ER: 400–800 mg once daily Take with or immediately after food
Naproxen 250–500 mg twice daily Take with or immediately after food
Fenbufen 900 mg/day (e.g. 300 mg AM, 600 mg PM) Take with or immediately after food
Piroxicam 10–20 mg once daily (max 20 mg/day) Take with or immediately after food
Floctafenine 200–400 mg every 6–8 hrs (max 1,200 mg/day) Take with or immediately after food
Proglumetacin 150–300 mg twice daily (max 600 mg/day) Take with or immediately after food
Flurbiprofen 50 mg 2–4 times/day or 100 mg twice/day (max 300 mg/day) Take with or immediately after food
Sulindac 150–200 mg twice daily (max 400 mg/day) Take with or immediately after food
Ibuprofen 400–800 mg 3–4 times/day (max 3,200 mg/day) Take with or immediately after food
Tenoxicam 20 mg once daily Take with or immediately after food
Indometacin 25 mg 2–3 times/day; may titrate weekly by 25–50 mg to max 150–200 mg/day Take with or immediately after food
Tiaprofenic acid 200–300 mg 2–3 times/day (max 600 mg/day) Take with or immediately after food
Ketoprofen Cap: 100 mg twice daily (max 300 mg/day); PR cap: 100–200 mg once daily (max 200 mg/day) Take with or immediately after food

Recommendations:

COX-2 Selective NSAIDs Dosage and Administration

Drug Adult Dosage (D) Administration (A)
Celecoxib 200 mg once or twice daily (maximum 400 mg/day) May be taken on an empty stomach or after meals
Etoricoxib 30–90 mg once daily May be taken on an empty stomach or after meals

3 .Other Musculoskeletal Medications

4. Muscle Relaxants

  • Centrally acting muscle relaxants (e.g., baclofen, eperisone, tizanidine, tolperisone): Used to reduce muscle tension. They may be combined with analgesics or NSAIDs. Physician guidance is recommended to ensure safe and effective use.
  • Orphenadrine: Possesses antimuscarinic properties and is commonly used to relieve muscle spasm-related pain. Drowsiness is a common side effect.

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