Viral Infection During Pregnancy Increases Risk of Seizures in Offspring

Sick Mother, At-Risk Child!

A comprehensive study involving over 1 million mother-child pairs has found that mothers who contract viral infections, such as influenza, during pregnancy particularly during the second and third trimesters (weeks 13–40) show a significant link to an increased risk of seizures or neurological issues in their children after birth.

The study highlights that infections occurring between weeks 32–36 of gestation are especially critical; children in this group face a 23% higher risk of seizures compared to the control group. Furthermore, infants born with a low birth weight (less than 2,500 grams) were also found to be at a higher risk than average.

How Do Viruses Affect a Baby's Brain?

Researchers explain that a viral infection can trigger systemic inflammation in the mother’s body, which in turn affects the developing immune system of the fetus. Specifically, it impacts cells called Microglia, which are responsible for maintaining and protecting the infant's brain.

If the function of these cells is disrupted, it can lead to abnormal neurodevelopment, manifesting as seizures or other neurological disorders later on. Therefore, it is vital for expectant mothers to maintain strict health precautions, especially during flu season.

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Reviewed by: Dr. Arun Rattanaprichan

Translated by : Pichapa Pungrung